![]() The development of other technologies also provides us a comprehensive dynamic data: DNA microarrays can practically measure mRNA expression responses of genes ( 4) technologies for globally and quantitatively measuring protein expression are also becoming feasible ( 5) and the two-hybrid system is enabling the construction of protein interaction maps ( 6). ![]() Since the first genome sequence of Haemophilus influenzae was published in 1995 ( 3), we have received many complete genome sequences, including Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Arabidopsis thaliana, Oryza Sativa, and Homo Sapiens, which help us to obtain the whole static information of genes, regulatory regions, proteins, tRNAs, repeats and so on underlying DNA sequences-the ultimate depository. ![]() The cause to accelerate such a change is the expansion of genome sequencing. , 2., but has not received renewed main attention until recently. The notion of system-level understanding in biology has a long history 1.
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